HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 12735383, compound → (S)-tert-butyl 1-(tert-butyldimethylsilyloxy)but-3-en-2-yl(3-cyclopropyl-2-oxobut-3-enyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 12735383 | HCID 12735383 | — |
| Reactant | (S)-tert-butyl 1-(tert-butyldimethylsilyloxy)but-3-en-2-yl(2-(methoxy(methyl)amino)-2-oxoethyl)carbamate | HCID 89855339 | — |
| Reactant | (S)-tert-butyl 1-(tert-butyldimethylsilyloxy)but-3-en-2-yl(4-methyl-3-methylene-2-oxopentyl)carbamate | HCID 131735279 | — |
| Product | (S)-tert-butyl 1-(tert-butyldimethylsilyloxy)but-3-en-2-yl(3-cyclopropyl-2-oxobut-3-enyl)carbamate | HCID 89852359 | — |
Reaction Steps
The title compound was prepared from (E)-N′-(1-cyclopropylethylidene)-2,4,6-triisopropylbenzenesulfonohydrazide (Intermediate 261, 17.58 g, 48.22 mmol) and (S)-tert-butyl 1-(tert-butyldimethylsilyloxy)but-3-en-2-yl(2-(methoxy(methyl)amino)-2-oxoethyl)carbamate (Intermediate 5, 9.71 g, 24.11 mmol) following the procedure described for Intermediate 34. The desired product was obtained as a light yellow oil (4.86 g, 49%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309245B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-441d22e938ea4befbd0f14c20f14fe60 |
| Source note | uspto-grants-2016_04 |