HRID627284

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N1CC(=O)C=C(CCO[Si](C)(C)C(C)(C)C)[C@H]1CO[Si](C)(C)C(C)(C)C

HCID89852111

未命名化合物

2 次

结构：CC1=C[C@@H](CO[Si](C)(C)C(C)(C)C)N(C(=O)OC(C)(C)C)C[C@H]1O

HCID89852486

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1C[C@@H](O)C=C(CCO[Si](C)(C)C(C)(C)C)[C@H]1CO[Si](C)(C)C(C)(C)C

HCID89852358

未命名化合物

收率 85.4%

PROCEDURE

实验过程

The title compound was prepared from (S)-tert-butyl 3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-oxo-5,6-dihydropyridine-1(2H)-carboxylate (Intermediate 280, 8.55 g, 17.11 mmol) according to the procedure described for Intermediate 8 to afford the desired product (7.33 g, 85%) as a light yellow oil.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-eda9e26ab3064241b2e55c7efda2771a
来源数据集: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09309245B2
来源说明: uspto-grants-2016_04

反应 SMILES

[Si:1]([O:8][CH2:9][CH2:10][C:11]1[C@@H:12]([CH2:25][O:26][Si:27]([C:30]([CH3:33])([CH3:32])[CH3:31])([CH3:29])[CH3:28])[N:13]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:14][C:15](=[O:17])[CH:16]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[Si](OC[C@@H]1C=C(C)[C@H](O)CN1C(OC(C)(C)C)=O)(C(C)(C)C)(C)C>>[Si:1]([O:8][CH2:9][CH2:10][C:11]1[C@@H:12]([CH2:25][O:26][Si:27]([C:30]([CH3:33])([CH3:32])[CH3:31])([CH3:28])[CH3:29])[N:13]([C:18]([O:20][C:21]([CH3:24])([CH3:22])[CH3:23])=[O:19])[CH2:14][C@@H:15]([OH:17])[CH:16]=1)([C:4]([CH3:7])([CH3:5])[CH3:6])([CH3:3])[CH3:2]