HRID627287

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=CCON([C@@H]1C=C(CCO[Si](C)(C)C(C)(C)C)[C@@H](CO[Si](C)(C)C(C)(C)C)NC1)S(=O)(=O)c1ccccc1[N+](=O)[O-]

HCID89852205

未命名化合物

2 次

结构：C=CCON[C@H]1CN[C@H](CO[Si](C)(C)C(C)(C)C)C=C1C

HCID131735277

未命名化合物

PRODUCTS

生成物

结构：C=CCON[C@@H]1C=C(CCO[Si](C)(C)C(C)(C)C)[C@@H](CO[Si](C)(C)C(C)(C)C)NC1

HCID131735304

未命名化合物

收率 86%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21226129

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from N-(allyloxy)-N-((3R,6S)-5-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6-(((tert-butyldimethylsilyl)oxy)methyl)-1,2,3,6-tetrahydropyridin-3-yl)-2-nitrobenzenesulfonamide (Intermediate 283, 6.49 g, 10.11 mmol) according to the procedure described for Intermediate 12. Silica gel chromatography (0%-5% methanol/dichloromethane) afforded the desired product (3.95 g, 86%) as a yellow oil.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2951360c1dd042379bb95059534ff87d
来源数据集: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09309245B2
来源说明: uspto-grants-2016_04

反应 SMILES

[CH2:1]([O:4][N:5]([C@@H:18]1[CH:23]=[C:22]([CH2:24][CH2:25][O:26][Si:27]([C:30]([CH3:33])([CH3:32])[CH3:31])([CH3:29])[CH3:28])[C@@H:21]([CH2:34][O:35][Si:36]([C:39]([CH3:42])([CH3:41])[CH3:40])([CH3:38])[CH3:37])[NH:20][CH2:19]1)S(C1C=CC=CC=1[N+]([O-])=O)(=O)=O)[CH:2]=[CH2:3].C(ON[C@@H]1C(C)=C[C@@H](CO[Si](C(C)(C)C)(C)C)NC1)C=C>CO.ClCCl>[CH2:1]([O:4][NH:5][C@@H:18]1[CH:23]=[C:22]([CH2:24][CH2:25][O:26][Si:27]([C:30]([CH3:33])([CH3:31])[CH3:32])([CH3:28])[CH3:29])[C@@H:21]([CH2:34][O:35][Si:36]([C:39]([CH3:42])([CH3:41])[CH3:40])([CH3:37])[CH3:38])[NH:20][CH2:19]1)[CH:2]=[CH2:3]