HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Boc-3,8-diaza-bicyclo(3.2.1)octane → HCID 67354448, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Boc-3,8-diaza-bicyclo(3.2.1)octane | HCID 15740908 | — |
| Reactant | 6-Amino-2-methylpyridine-3-carboxylic acid | HCID 28875529 | — |
| Product | HCID 67354448 | HCID 67354448 | 88.1% |
Reaction Steps
Following general amide formation method 1, 3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (279 mg, 1.31 mmol, 1.0 eq) was combined with 6-amino-2-methylnicotinic acid (200 mg, 1.31 mmol, 1.0 eq) which gave 3-(6-Amino-2-methyl-pyridine-3-carbonyl)-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (400 mg) in 88% yield. MS m/z 346.6 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309252B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-d4222da3fc32476dab810ba3d623efe2 |
| Source note | uspto-grants-2016_04 |