HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Amino-4-methylnicotinic acid → HCID 67357152, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Amino-4-methylnicotinic acid | HCID 9964149 | — |
| Reactant | 8-Boc-3,8-diaza-bicyclo(3.2.1)octane | HCID 15740908 | — |
| Product | HCID 67357152 | HCID 67357152 | 55.3% |
Reaction Steps
Following general amide formation method 1, 3,8-Diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (279 mg, 1.31 mmol, 1.0 eq) was combined with 6-Amino-4-methylnicotinic acid (200 mg, 1.31 mmol, 1.0 eq) to give 3-(6-Amino-4-methyl-pyridine-3-carbonyl)-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (251 mg) in 55% yield. MS m/z 347.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309252B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-870792cf2f764d71a91b0bd7672b5c67 |
| Source note | uspto-grants-2016_04 |