Methyl 4-(3,4-di-tert-butoxy-5-chlorobenzamido)benzoate → 4-(3,4-Di-tert-butoxy-5-chlorobenzamido)benzoic acid

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Reaction Steps

4-(3,4-Di-tert-butoxy-5-chlorobenzamido)benzoic acid (AAA-048) (110 mg, 64%) was prepared from methyl 4-(3,4-di-tert-butoxy-5-chlorobenzamido)benzoate (5) (175 mg, 0.403 mmol) using a procedure essentially the same as in Step (ii) for AAA-001, except that 1,4-dioxane (6 mL) was used instead of THF: m/z 418 [M−H]− (ES−); 1H NMR (400 MHz, DMSO-d6) δ: 12.78 (1H, br s). 10.49 (1H, s), 7.93 (2H, d), 7.87 (2H, d), 7.85 (1H, d), 7.59 (1H, d), 1.40 (9H, s), 1.34 (9H, s).

Provenance & Evidence