HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)nicotinic acid → HCID 67355223, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)nicotinic acid | HCID 58315472 | — |
| Reactant | HCID 67354905 | HCID 67354905 | — |
| Product | HCID 67355223 | HCID 67355223 | 59% |
Reaction Steps
Following general amide formation method 3, 6-(7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)nicotinic acid (385 mg, 0.97 mmole) was combined with 8-Oxa-3,10-diaza-bicyclo[4.3.1]decane-10-carboxylic acid tert-butyl ester (215 mg, 0.887 mmol) which gave 3-[6-(7-Cyclopentyl-6-dimethylcarbamoyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-pyridine-3-carbonyl]-8-oxa-3,10-diaza-bicyclo[4.3.1]decane-10-carboxylic acid tert-butyl ester (323 mg, 0.522 mmol) in 59% yield. MS 619.7 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309252B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-780ed86a7cd84c9bad9e64c025fde968 |
| Source note | uspto-grants-2016_04 |