HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-nitropyridine → HCID 67354818, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-nitropyridine | HCID 817620 | — |
| Reactant | tert-Butyl 6-oxo-1,7-diazaspiro[4.4]nonane-1-carboxylate | HCID 49760540 | — |
| Product | HCID 67354818 | HCID 67354818 | 79.1% |
Reaction Steps
Following general N—C coupling procedure 1, 6-oxo-1,7-diaza-spiro[4,4]nonan-1-carboxylic acid tert-butyl ester (1.3 g, 5.41 mmol) was combined with 5-bromo-2-nitropyridine (1.10 g, 5.41 mmol) which gave 7-(6-nitro-pyridin-3-yl)-6-oxo-1,7-diaza-spiro[4,4]nonane-1-carboxylic acid tert-butyl ester (1.55 g) in 79% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309252B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-d38b419b977d4687b24f52984ad7db88 |
| Source note | uspto-grants-2016_04 |