HCID 67354835, compound → HCID 67355305, compound

Participants

Reaction Steps

Following general N—C coupling procedure 1, 2-chloro-7-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (181 mg, 0.602 mmol) was combined with 3-(6-amino-pyridin-3-yl)-4-oxo-3,9-diaza-bicyclo[4.2.1]nonane-9-carboxylic acid tert-butyl ester (200 mg, 0.602 mmol), which gave 3-[6-(6-dimethylcarbamoyl-7-phenyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-pyridin-3-yl]-4-oxo-3,9-diaza-bicyclo[4.2.1]nonane-9-carboxylic acid tert-butyl ester (320 mg, 0.536 mmol) in 86% yield.

Provenance & Evidence