Sodium Hydroxide → 6-Bromo-3-phenylquinolin-4(1H)-one

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 3-((4-bromophenyl)imino)-2-phenylpropanoate (6.18 g, 17.8 mmol, Intermediate 3, step a) and polyphosphoric acid (8.90 g) was heated at 150° C. for 1.5 hours. After cooling to room temperature, 3 N NaOH was added at 4° C. until basic. The solid was filtered, washed with water, and dried under vacuum overnight to give the title compound.

Provenance & Evidence