反应详情

In a 100-mL round-bottom flask was placed a mixture of 6-bromo-2-chloro-3-phenylquinoline (550 mg, 1.73 mmol, Intermediate 4, step b) and NaOCH3 (931 mg, 17.2 mmol) in methanol (50 mL). The resulting mixture was refluxed for 5 hours and concentrated under vacuum. The residue was purified by chromatography (silica gel column, 1:5 EtOAc/petroleum ether) to provide the title compound as a white solid.

1. customIn a 100-mL round-bottom flask was placed
2. temperatureThe resulting mixture was refluxed for 5 hours
3. concentrationconcentrated under vacuum
4. customThe residue was purified by chromatography (silica gel column, 1:5 EtOAc/petroleum ether)