反应详情

温度

75 °C

In a 50-mL round-bottom flask was placed a solution of Na (260 mg, 11.3 mmol) in methanol (15 mL) and the solution was stirred for 30 min at room temperature. Then 2-chloro-5-[(1-methyl-1H-imidazol-5-yl)carbonyl]pyridine (250 mg, 1.13 mmol, Intermediate 22, step c) was added. The resulting mixture was stirred for 4 hours at 75° C. and concentrated under vacuum. The residue was purified by flash column chromatography (silica gel column, 100:0-20:1 CH2Cl2/MeOH) to give the title compound as a light yellow solid.

1. customIn a 50-mL round-bottom flask was placed
2. concentrationconcentrated under vacuum
3. customThe residue was purified by flash column chromatography (silica gel column, 100:0-20:1 CH2Cl2/MeOH)