反应详情

温度

100 °C

A mixture of 2-amino-5-bromobenzoic acid (3.01 g, 13.9 mmol), 1,1,1-trifluoro-3-phenylpropan-2-one (3.11 g, 16.5 mmol), and Eaton's reagent (9.3 mL) in a sealed tube was heated at 100° C. for 4 hours. The reaction mixture was then allowed to cool to room temperature, water was added slowly, and the mixture was stirred vigorously for about 15 min. The precipitated solid was filtered, washed with water, and dried to give the title compound.

1. temperatureto cool to room temperature
2. filtrationThe precipitated solid was filtered
3. washwashed with water
4. customdried