Methyl 4-(4-chloro-3,5-diisopropoxybenzamido)benzoate → 4-(4-Chloro-3,5-diisopropoxybenzamido)benzoic acid

Participants

Reaction Conditions

Reaction Steps

4-(4-Chloro-3,5-diisopropoxybenzamido)benzoic acid (AAA-112) (40 mg, 46%) was prepared from methyl 4-(4-chloro-3,5-diisopropoxybenzamido)benzoate (8) (86 mg, 0.21 mmol) using a procedure essentially the same as in step (ii) for AAA-001 except that MeOH was added dropwise to obtain a solution and the mixture was heated at 50° C. for 2 h then at RT for 15 h: m/z 390 [M−H]− (ES−), 1H NMR (400 MHz, DMSO-d6) δ: 12.74 (1H, br s), 10.44 (1H, s), 8.01-7.84 (4H, m), 7.29 (2H, s), 4.78 (2H, sep), 1.33 (12H, d).

Provenance & Evidence