Methylamine → HCID 86716107, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol (28 mg, 0.0607 mmol, Example 16), 33% MeNH2 in EtOH (0.8 mL), and trifluoroacetic acid (0.050 mL, 0.653 mmol) was heated at 80° C. for 17 hours. After cooling to room temperature, the mixture was diluted with DMF and purified by reverse phase HPLC (water/acetonitrile/0.1% TFA) to give the title compound. 1H NMR (400 MHz, MeOH-d4) δ 9.08 (s, 1H), 8.74-8.83 (m, 2H), 8.49 (d, J=1.71 Hz, 1H), 7.98 (dt, J=1.93, 6.91 Hz, 3H), 7.86 (d, J=8.80 Hz, 1H), 7.47-7.55 (m, 3H), 7.35-7.46 (m, 2H), 7.25 (d, J=1.47 Hz, 1H), 3.69 (s, 3H), 2.58 (s, 3H); MS m/e 456.1 [M+H]+.

Provenance & Evidence