Hydrochloric Acid → HCID 86716108, compound

Participants

Reaction Steps

(2,4-Dichloro-3-phenylquinolin-6-yl)[4-(methoxymethoxy)phenyl]pyridin-3-ylmethanol (20 mg, 0.039 mmol, Example 23) in MeOH (2 mL) was treated with 37% HCl (1 mL) at room temperature for 18 hours, and concentrated. The residue was purified by reverse phase HPLC (water/acetonitrile/0.1% TFA) to give the title compound as an off-white solid. 1H NMR (400 MHz, MeOH-d4) δ 8.85 (d, J=2.20 Hz, 1H), 8.75 (d, J=4.89 Hz, 1H), 8.48 (dt, J=1.80, 8.13 Hz, 1H), 8.31 (d, J=1.96 Hz, 1H), 8.02 (d, J=9.05 Hz, 1H), 7.95 (dd, J=5.62, 8.31 Hz, 1H), 7.86 (dd, J=1.96, 8.80 Hz, 1H), 7.48-7.57 (m, 3H), 7.33 (dd, J=1.47, 7.83 Hz, 2H), 7.08-7.16 (m, 2H), 6.77-6.84 (m, 2H); MS m/e 473.0 [M+H]+.

Provenance & Evidence