(4-Methoxyphenyl)-3-pyridinylmethanone → (4-Chloro-3-phenylquinolin-6-yl)(4-methoxyphenyl)pyridin-3-ylmethanol

Participants

Reaction Steps

The title compound was prepared using 6-bromo-4-chloro-3-phenylquinoline (Intermediate 3, step c) and (4-methoxyphenyl)(pyridin-3-yl)methanone in place of 6-bromo-2,4-dichloro-3-phenylquinoline and (3-chlorophenyl)(pyridin-3-yl)methanone, respectively, according to the procedure described in Example 25. 1H NMR (400 MHz, CDCl3) δ 8.81 (s, 1H), 8.60-8.68 (m, 1H), 8.51-8.57 (m, 1H), 8.38 (d, J=1.96 Hz, 1H), 8.08 (d, J=8.80 Hz, 1H), 7.67-7.78 (m, 2H), 7.44-7.57 (m, 5H), 7.25-7.32 (m, 1H), 7.20 (d, J=8.80 Hz, 2H), 6.88 (d, J=8.80 Hz, 2H), 3.81 (s, 3H); MS m/e 452.9 [M+H]+.

Provenance & Evidence