(3-Chlorophenyl)(pyridin-3-yl)methanone → (3-Chlorophenyl)(4-chloro-3-phenylquinolin-6-yl)(6-chloropyridin-3-yl)methanol

Participants

Reaction Steps

The title compound was prepared using 6-bromo-4-chloro-3-phenylquinoline (Intermediate 3, step c) and (3-chlorophenyl)(6-chloropyridin-3-yl)methanone in place of 6-bromo-2,4-dichloro-3-phenylquinoline and (3-chlorophenyl)(pyridin-3-yl)methanone, respectively, according to the procedure described in Example 25. 1H NMR (400 MHz, CDCl3) δ 8.81 (s, 1H), 8.40 (d, J=2.69 Hz, 1H), 8.29 (d, J=2.20 Hz, 1H), 8.10 (d, J=9.05 Hz, 1H), 7.70 (dd, J=2.69, 8.31 Hz, 1H), 7.65 (dd, J=2.08, 8.93 Hz, 1H), 7.47-7.54 (m, 5H), 7.37 (d, J=1.47 Hz, 1H), 7.31-7.35 (m, 3H), 7.18 (dt, J=1.80, 7.15 Hz, 1H); MS m/e 490.8 [M+H]+.

Provenance & Evidence