(4-Butyl-2-chloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol.TFA → (4-Butyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol.TFA

Participants

Reaction Conditions

Reaction Steps

A mixture of (4-butyl-2-chloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)pyridin-4-ylmethanol•TFA (16 mg, 0.023 mmol, Example 78) and NaOiPr (19 mg, 0.23 mmol) in iPrOH (0.4 mL) was heated in a sealed tube at 80° C. for 17 hours, and more NaOiPr (7 mg, 0.085 mmol) was added. The mixture was heated for 64 hours and purified by reverse phase HPLC (water/acetonitrile/0.1% TFA) to provide the title compound. 1H NMR (400 MHz, MeOH-d4) δ 9.08 (s, 1H), 8.90 (s, 1H), 8.77 (d, J=6.57 Hz, 3H), 8.29 (d, J=2.02 Hz, 1H), 8.24 (d, J=8.59 Hz, 1H), 8.03 (dd, J=2.02, 9.09 Hz, 1H), 7.83 (d, J=6.57 Hz, 2H), 7.53-7.58 (m, 2H), 7.43 (d, J=6.06 Hz, 2H), 7.18 (s, 1H), 3.72 (s, 3H), 3.06-3.12 (m, 2H), 1.45-1.55 (m, 2H), 1.19-1.28 (m, 2H), 0.78 (t, J=7.33 Hz, 3H); MS m/e 449.2 [M+H]+.

Provenance & Evidence