1-Acetyl-4-benzoylpiperidine → 1-(4-(Hydroxy(phenyl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidin-1-yl)ethanone

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Reaktionsschritte

A ˜−70° C. solution of 6-iodo-3-phenyl-2,4-bis(trifluoromethyl)quinoline (754 mg, 1.61 mmol, Intermediate 8, step d) in THF (1.4 mL) was treated with iPrMgCl (0.784 mL, 2.06 M in THF, 1.61 mmol) dropwise via syringe under argon over the course of 3 min to provide a light amber solution. After 9 min, the opaque yellow slurry was removed from the cold bath and stirred under ambient conditions for 4 min. A solution of 1-(4-benzoylpiperidin-1-yl)ethanone (442 mg, 1.91 mmol, Intermediate 27) in THF (0.3 mL) was added to the olive drab slurry rapidly dropwise over ˜15 sec, and the homogeneous brown solution was stirred at room temperature overnight. The light amber solution was then quenched with 5 M NH4Cl (1 mL) and extracted with 2-methoxy-2-methylpropane (1×10 mL, 1×2 mL), and the combined organic layers were dried (Na2SO4), filtered, and concentrated. The residue was flash chromatographed using 50% acetone/heptane (isocratic elution), and impure fractions were additionally flash chromatographed using 90% EtOAc/heptanes (isocratic elution) to afford the title compound as an off-white foam. 1H NMR (400 MHz, CDCl3) δ 8.52 (d, J=10.11 Hz, 1H), 8.24 (dd, J=5.56, 9.09 Hz, 1H), 7.94 (t, J=8.84 Hz, 1H), 7.54 (t, J=7.33 Hz, 2H), 7.41-7.51 (m, 3H), 7.33-7.41 (m, 2H), 7.28 (br. s., 3H), 4.71 (d, J=7.58 Hz, 1H), 3.86 (br. s., 1H), 3.00-3.21 (m, 1H), 2.74-2.89 (m, 1H), 2.52-2.69 (m, 1H), 2.44-2.52 (m, 1H; D2O-exch), 2.05 (d, J=2.02 Hz, 3H), 1.69-1.84 (m, 1H), 1.31-1.55 (m, 3H); MS m/e 573.0 [M+H]+.

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