Tetrahydrofuran → (4-Chloro-2-methoxy-8-methyl-3-(4-(trifluoromethoxy)phenyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol.TFA

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n-Butyllithium (2.0 mL, 3.202 mmol) was added to a −78° C. mixture of 6-bromo-4-chloro-2-methoxy-8-methyl-3-(4-(trifluoromethoxy)phenyl)quinoline (1.1 g, 2.463 mmol, Intermediate 58, step d) and (1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanone (0.691 g, 2.709 mmol, Intermediate 15, step c) in dry THF (25 mL) over a 2 min period. After complete addition stirring was continued at −78° C. for 10 min then the reaction was warmed up to 0° C. and stirred for 1 hour. Saturated NH4Cl was added and the reaction mixture slowly warmed to room temperature. Water was added and the layers were separated. The aqueous layer was extracted with EtOAc. The combined organic extracts was dried (Na2SO4), filtered, evaporated in vacuo and chromatographed (DCM/10% MeOH in EtOAc) to provide product. Further purification using reverse phase HPLC provided the TFA salt of the title compound. MS (ESI) 623.1

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