反应详情

50 g (0.219 mole) of a mixture of 2,4-dihydroxy-phenyl-benzyl-ketone, 20 ml of dimethyl-formamide, 2.6 ml of morpholine and 39.06 g (0.26 mole) of ethyl-orthoformate is stirred for 7 hours at 80°-90° C. After 25 minutes crystallization can be observed. At the end of the reaction time the crystallized suspension is diluted with 120 ml of chloroform and it is crystallized at 0° C. for 2 hours. After filtration the product is covered twice with 45 ml of chloroform and dried. 47.9 g of 7-hydroxy-isoflavone are obtained.

1. customAfter 25 minutes crystallization
2. additionAt the end of the reaction time the crystallized suspension is diluted with 120 ml of chloroform and it
3. customis crystallized at 0° C. for 2 hours
4. filtrationAfter filtration the product
5. customdried