Methyl 5-(2,2-difluoroethoxy)-3-methylpyrazine-2-carboxylate → 5-(2,2-Difluoroethoxy)-3-methylpyrazine-2-carboxylic acid

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Reaction Steps

A mixture of methyl 5-(2,2-difluoroethoxy)-3-methylpyrazine-2-carboxylate (63.8 mg, 0.275 mmol) in aqueous 2N HCl (1 mL) and Dioxane (2 mL) was stirred at ambient temperature for 20 hrs. The reaction was concentrated and the resulting solid was rinsed with acetonitrile. The filtrate was collected and concentrated in vacuo to give the title compound (60 mg, 0.275 mmol, 100%) as a white solid. MS m/z=219.1 (M+H).

Provenance & Evidence