反应详情

A round bottom flask was charged with 3-nitro-5-(trifluoromethyl)picolinamide (850 mg, 3.62 mmol) and wet 5 wt. % Pd/C (769 mg, 0.362 mmol) and was purged with nitrogen. EtOAc (7230 μl) and then MeOH (7230 μl) were added, and the flask was evacuated and filled with hydrogen. The reaction was stirred at RT under hydrogen atmosphere for 17 h. The mixture was filtered through Celite and washed with EtOAc and MeOH. The filtrate was concentrated to provide 3-amino-5-(trifluoromethyl)picolinamide (720 mg, 3.51 mmol, 97% yield) as a white solid. LC/MS (ESI+) m/z=206.1 (M+H).

1. customwas purged with nitrogen
2. additionEtOAc (7230 μl) and then MeOH (7230 μl) were added
3. customthe flask was evacuated
4. additionfilled with hydrogen
5. filtrationThe mixture was filtered through Celite
6. washwashed with EtOAc and MeOH
7. concentrationThe filtrate was concentrated