反应详情

To the product of Example 38a (279.8 mg) was added methanol (7.5 mL) and 10% palladium on carbon (76 mg, 0.071 mmol). The flask was fitted with a hydrogen balloon and the mixture was de-gased and back-filled with hydrogen three times. The mixture was stirred under hydrogen for 16 h, diluted with dimethylformamide and filtered. The filtrate was concentrated to give a red solid. This material was triturated with dichloromethane/hexane (9/1) and filtered to provide the title compound (Example 38b, 43.15 mg, 0.175 mmol, quantitative yield).

1. customthe mixture was de-gased
2. additionback-filled with hydrogen three times
3. additiondiluted with dimethylformamide
4. filtrationfiltered
5. concentrationThe filtrate was concentrated
6. customto give a red solid
7. customThis material was triturated with dichloromethane/hexane (9/1)
8. filtrationfiltered