Benzoylhydrazine → HCID 3788919, compound

Participants

Reaction Steps

First, 16.7 g (123.3 mmol) of benzoylhydrazine and 100 mL of N-methyl-2-pyrrolidinone (NMP) were put into a 300-mL three-neck flask and stiffed under nitrogen flow while being cooled with ice. To this mixed solution, a mixed solution of 25.0 g (137.3 mmol) of 2,4,6-trimethylbenzoyl chloride and 20 mL of NMP was slowly added dropwise, and the mixture was stiffed at room temperature for 24 hours. After reaction for the predetermined time, this reacted solution was slowly added to 500 mL of water, so that a white solid was precipitated. The precipitated solid was washed by repeating twice ultrasonic cleaning in which water and then 1M hydrochloric acid were used. Then, ultrasonic cleaning using hexane was performed, so that 22.7 g of a white solid of 1-(2,4,6-trimethylbenzoyl)-2-benzoylhydrazine was obtained in a yield of 65%. A synthesis scheme of Step 1 is shown in (e-1).

Provenance & Evidence