HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → 2-(2-Dodecanoylamino-3-hydroxybutanoylamino)-3-hydroxybutanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 2-amino-3-hydroxybutanoate | HCID 324007 | — |
| Reactant | 2-Dodecanoylamino-3-hydroxybutanoic acid | HCID 9879439 | — |
| Product | 2-(2-Dodecanoylamino-3-hydroxybutanoylamino)-3-hydroxybutanoic acid | HCID 23132027 | 50.9% |
Reaction Steps
2-Dodecanoylamino-3-hydroxybutanoic acid (15.07 g) and 2-amino-3-hydroxybutanoic acid methyl ester (6.66 g) were condensed with dicyclohexylcarbodiimide (10.31 g). Thereafter, methyl ester was hydrolyzed with sodium hydroxide to give 2-(2-dodecanoylamino-3-hydroxybutanoylamino)-3-hydroxybutanoic acid (10.24 g). The structure thereof was identified by 1H-NMR (400 MHz, CD3OD, r.t.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309486B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-ce3ddd5890474d97b0bb179d4da7e76c |
| Source note | uspto-grants-2016_04 |