化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl 4-bromobutyrate → Ethyl 4-phenoxybutanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 4-bromobutyrate | HCID 76300 | — |
| 反応物 | 2,3,4,5-Tetrahydro-1-benzoxepin-5-one | HCID 315575 | — |
| 生成物 | Ethyl 4-phenoxybutanoate | HCID 222539 | — |
反応手順
Scheme 1 shows a general method for preparation of 3,4-dihydrobenzo[b]oxepin-5(2H)-one intermediates 66 by O-alkylation of a phenolic compound with ethyl 4-bromobutanoate to give a ethyl 4-phenoxybutanoate intermediate 67, followed by saponification to the carboxylic acid 68 and intramolecular cyclization under acidic conditions.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09309265B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-ec2febbd2972479897bd73bff152f385 |
| 出典メモ | uspto-grants-2016_04 |