Tetrahydrofuran → 2-Iodo-3-(2-thiophen-3-ylethoxy)-pyridine

関与物質

役割	名称	HCID	仕込み量
反応物	Tetrahydrofuran	HCID 8028	—
反応物	Triphenylphosphine	HCID 11776	—
反応物	Diisopropyl diazene-1,2-dicarboxylate	HCID 75555	—
反応物	Thiophene-3-ethanol	HCID 83731	—
反応物	2-Iodopyridin-3-ol	HCID 97179	—
生成物	2-Iodo-3-(2-thiophen-3-ylethoxy)-pyridine	HCID 57900311	90%

反応手順

To a solution containing 2-iodo-3-hydroxypyridine 12 (1.85 g, 8.37 mmol), 2-(3-thienyl)ethanol (1.20 mL, 10.9 mmol), and triphenylphosphine (2.85 g, 10.9 mmol) in tetrahydrofuran (46.2 mL, 5.70 mmol) was added diisopropyl azodicarboxylate (2.14 mL, 10.9 mmol) dropwise. The reaction mixture was stirred at room temperature for 18 h. The reaction mixture was concentrated and purified by flash chromatography EtOAc/Hex (0-100%) eluted at 30% to give 13 (yield 90%). MS: (ESI+) 332.2

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09309265B2
出典データセット	uspto-grants-2016_04
ORD ID	ord-ac00b591bdbc4c4d901eefaf6f43c6eb
出典メモ	uspto-grants-2016_04