3-(Methylsulfonyl)phenylboronic acid → N-(2-chlorophenyl)-N-methyl-8-(3-(methylsulfonyl)phenyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	3-(Methylsulfonyl)phenylboronic acid	HCID 2773542	—
Reactant	8-bromo-N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide	HCID 44242427	—
Product	N-(2-chlorophenyl)-N-methyl-8-(3-(methylsulfonyl)phenyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide	HCID 57900237	—

Reaction Steps

Following the procedure of Examples 44 and 60 and General Procedure C, 8-bromo-N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide 150 and 3-methylsulfonylphenyl boronic acid were reacted to give 146. MS: (ESI+) 524.1

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09309265B2
Source dataset	uspto-grants-2016_04
ORD ID	ord-9658799bad844458af3718b6ba30506c
Source note	uspto-grants-2016_04