HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 4-Bromo-3,4-dihydro-2H-benzo[b]oxepin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 2,3,4,5-Tetrahydro-1-benzoxepin-5-one | HCID 315575 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4-Bromo-3,4-dihydro-2H-benzo[b]oxepin-5-one | HCID 13863234 | — |
Reaction Steps
To a solution of 3,4-dihydro-2H-benzo[b]oxepin-5-one (3.10 g, 12.8 mmol) in diethyl ether at 0° C., bromine (625 μl, 12.2 mmol) was added and stirred for 2.5 hours, gradually raising the temperature to room temperature. Purification on silica and triturating using diethyl ether and hexanes gave 4-bromo-3,4-dihydro-2H-benzo[b]oxepin-5-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309265B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-dc673192a1da4bf8bf33319e025afa48 |
| Source note | uspto-grants-2016_04 |