N-(2-aminoethyl)acetamide → N-(4-(2-acetamidoethylcarbamoyl)-2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	N-(2-aminoethyl)acetamide	HCID 66082	—
Reactant	3-Chloro-4-(N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)benzoic acid	HCID 66868923	—
Product	N-(4-(2-acetamidoethylcarbamoyl)-2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide	HCID 57900276	—

Reaction Steps

3-Chloro-4-(N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)benzoic acid and N-(2-aminoethyl)acetamide were reacted by a procedure similar to that to prepare 137 in Example 47 to give 230. MS: (ESI+) 498.1

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09309265B2
Source dataset	uspto-grants-2016_04
ORD ID	ord-32dc42ffe6e84109bbb5b102f39a777d
Source note	uspto-grants-2016_04