Morpholine → N-(2-(4-(2-chlorophenyl)-4H-1,2,4-triazol-3-yl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-8-yl)-2-morpholinoacetamide

HRID 627952Notes

Reaction equation

HRID 627952 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:7]=[CH:8][C:9]2[C:15]3[S:16][C:17]([C:19]4[N:23]([C:24]5[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=5[Cl:30])[CH:22]=[N:21][N:20]=4)=[CH:18][C:14]=3[CH2:13][CH2:12][O:11][C:10]=2[CH:31]=1)=[O:4].[NH:32]1[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1>>[Cl:30][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[N:23]1[CH:22]=[N:21][N:20]=[C:19]1[C:17]1[S:16][C:15]2[C:9]3[CH:8]=[CH:7][C:6]([NH:5][C:3](=[O:4])[CH2:2][N:32]4[CH2:37][CH2:36][O:35][CH2:34][CH2:33]4)=[CH:31][C:10]=3[O:11][CH2:12][CH2:13][C:14]=2[CH:18]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 57900378HCID 57900378, compound

Product 1

HCID 57900452N-(2-(4-(2-chlorophenyl)-4H-1,2,4-triazol-3-yl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-8-yl)-2-morpholinoacetamide

Procedure

Following the procedure in Example 147 for 237, 2-chloro-N-(2-(4-(2-chlorophenyl)-4H-1,2,4-triazol-3-yl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-8-yl)acetamide was reacted with morpholine to give 236. MS: (ESI+) 522.3

Sources & evidence

ORD record
ord-d0eb0a8b45844287848902ef21ca2184
Source dataset
uspto-grants-2016_04
Patent number
US09309265B2

Reaction notes

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