Hydrazine → HCID 178478016, compound

HRID 627984Notes

Reaction equation

HRID 627984 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11]3[S:12][C:13]([C:15](=O)[C:16]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[Cl:27])=[CH:17][N:18](C)C)=[CH:14][C:10]=3[CH2:9][CH2:8][O:7][C:6]=2[CH:29]=1.[NH2:30]N>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11]3[S:12][C:13]([C:15]4[C:16]([C:21]5[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=5[Cl:27])=[CH:17][NH:18][N:30]=4)=[CH:14][C:10]=3[CH2:9][CH2:8][O:7][C:6]=2[CH:29]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 66868810HCID 66868810, compound

Product 1

HCID 178478016HCID 178478016, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Crude 1-(8-bromo-4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-2-yl)-2-(2-chlorophenyl)-3-(dimethylamino)prop-2-en-1-one was suspended in methanol (5 mL) and treated with hydrazine (ca. 1 mL). After 2 h, the mixture was concentrated and the residue purified by flash column chromatography to give 276 as colorless solid (527 mg). MS (ESI): 459.0

Workup

  1. concentrationthe mixture was concentrated
  2. customthe residue purified by flash column chromatography

Sources & evidence

ORD record
ord-88b4e288a8204964a84b1a0f9136cfcf
Source dataset
uspto-grants-2016_04
Patent number
US09309265B2

Reaction notes

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