Acetic Acid → HCID 57900090, compound

HRID 628044Notes

Reaction equation

HRID 628044 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11]3[S:12][C:13]([C:15]([NH2:17])=O)=[CH:14][C:10]=3[CH2:9][CH2:8][O:7][C:6]=2[CH:18]=1.[Cl:19][C:20]1[CH:21]=[C:22]([CH:28]=[CH:29][C:30]=1[NH:31][NH2:32])[C:23]([N:25]([CH3:27])[CH3:26])=[O:24].[C:33](O)(=O)C>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11]3[S:12][C:13]([C:15]4[N:31]([C:30]5[CH:29]=[CH:28][C:22]([C:23]([N:25]([CH3:27])[CH3:26])=[O:24])=[CH:21][C:20]=5[Cl:19])[N:32]=[CH:33][N:17]=4)=[CH:14][C:10]=3[CH2:9][CH2:8][O:7][C:6]=2[CH:18]=1

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 57900484HCID 57900484, compoundHCID 58265765HCID 58265765, compound

Product 1

HCID 57900090HCID 57900090, compound

Procedure

Following the procedure from Example 235, 8-bromo-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide was reacted with 3-chloro-4-hydrazinyl-N,N-dimethylbenzamide in acetic acid to give 342 as a colorless solid after purification by flash column chromatography (50-100% ethyl acetate in hexanes). MS: (ESI+) 531.0

Sources & evidence

ORD record
ord-7c867a8549b147cab8e0214171a42ccb
Source dataset
uspto-grants-2016_04
Patent number
US09309265B2

Reaction notes

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