Dimethylamine → HCID 44241894, compound

HRID 628102Notes

Reaction equation

HRID 628102 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]([CH3:28])[C:10]([C:12]1[S:24][C:23]2[C:22]3[CH:21]=[C:20]([C:25](O)=[O:26])[CH:19]=[CH:18][C:17]=3[O:16][CH2:15][C:14]=2[CH:13]=1)=[O:11].[CH3:29][NH:30][CH3:31]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]([CH3:28])[C:10]([C:12]1[S:24][C:23]2[C:22]3[CH:21]=[C:20]([C:25]([N:30]([CH3:31])[CH3:29])=[O:26])[CH:19]=[CH:18][C:17]=3[O:16][CH2:15][C:14]=2[CH:13]=1)=[O:11]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 57900153HCID 57900153, compound

Product 1

HCID 44241894HCID 44241894, compound

Procedure

Following the procedure of Example 15 and General Procedure C, 2-((2,4-difluorophenyl)(methyl)carbamoyl)-4H-thieno[3,2-c]chromene-8-carboxylic acid and dimethylamine were coupled to give 111bp. 1H NMR (400 MHz, CDCl3) δ 7.15-7.31 (m, 3H), 6.82-7.00 (m, 4H), 5.13 (s, 2H), 3.33 (m, 3H), 2.94-3.13 (m, 6H). LCMS (ESI) m/z: 429.1.

Workup

  1. customto give 111bp

Sources & evidence

ORD record
ord-b06428c63c2c42eab88d5f84712fdfc2
Source dataset
uspto-grants-2016_04
Patent number
US09309265B2

Reaction notes

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