1-Methylpiperazine → N-(2,4-difluorophenyl)-N-methyl-8-(4-methylpiperazin-1-yl)-4H-thieno[3,2-c]chromene-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	1-Methylpiperazine	HCID 53167	—
Reactant	8-bromo-N-(2,4-difluorophenyl)-N-methyl-4H-thieno[3,2-c]chromene-2-carboxamide	HCID 57900337	—
Product	N-(2,4-difluorophenyl)-N-methyl-8-(4-methylpiperazin-1-yl)-4H-thieno[3,2-c]chromene-2-carboxamide	HCID 44242026	—

Reaction Steps

Following Example 70 and General Procedure D, 8-bromo-N-(2,4-difluorophenyl)-N-methyl-4H-thieno[3,2-c]chromene-2-carboxamide 160bp and N-methylpiperazine were reacted to give 128bp. 1H NMR (400 MHz, CDCl3) δ 7.30 (m, 1H), 6.94-7.00 (m, 2H), 6.85 (m, 1H), 6.75-6.82 (m, 2H), 6.68 (s, 1H), 5.03 (s, 2H), 3.69 (m, 2H), 3.46 (m, 2H), 3.39 (s, 3H), 3.30 (m, 2H), 3.07 (m, 2H), 2.90 (s, 3H). LCMS (ESI) m/z: 456.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09309265B2
Source dataset	uspto-grants-2016_04
ORD ID	ord-dc178fbec8de4587afb87ef858fc36df
Source note	uspto-grants-2016_04