HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3-(Chlorosulfonyl)-4-fluorobenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(Chlorosulfonyl)-4-fluorobenzoic acid | HCID 3929891 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 3-(Chlorosulfonyl)-4-fluorobenzoyl chloride | HCID 58107439 | — |
Reaction Steps
3-(Chlorosulfonyl)-4-fluorobenzoic acid (1, 2.50 g, 10.5 mmol), thionyl chloride (10 mL) and DMF (1 drop) were heated at 90° C. for 1 hour and then the mixture evaporated to dryness. The material was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309283B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-0d81ebdcd29843118ce9e289125ed5c6 |
| Source note | uspto-grants-2016_04 |