Triethylamine → HCID 86696062, compound

Participants

Reaction Steps

The synthesis started out from 2-phenyl-7-chlorocarbonyl-4H-3,1-benzoxazin-4-one, whose synthesis is descried in L. Jakisch et al., Journal of Polymer Science: Part A: Polymer Chemistry 2003; 41(5): 655-667 (there compound 10a). 2.855 g (10 mmol) of this substance was suspended in 100 ml of dry tetrahydrofuran at 0° C. in a 250 ml three-necked flask provided with magnetic stirrer, reflux condenser and drying tube. A mixture of 1.854 g (10 mmol) of n-dodecylamine, 1.012 g (10 mmol) of triethylamine and 20 ml of dry tetrahydrofuran was then slowly added dropwise at from 0 to 5° C. The reaction mixture was subsequently stirred at room temperature for 2 hours, and the resultant precipitate of triethylammonium chloride was then filtered off with suction and the filtrate was evaporated on a rotary evaporator. The solid residue was washed with water and dried at 60° C. under reduced pressure. Recrystallization from ethanol gave 2.85 g of product.

Provenance & Evidence