Thiophene-3-carboxylic acid → 5-Bromothiophene-3-carboxylic acid

Participants

Reaction Steps

Under a nitrogen atmosphere, 3-thiophenecarboxylic acid (10 g, 78 mmol) was added to acetic acid (100 ml), and bromine (12.5 g, 78 mmol) was then slowly dropped and stirred at the same temperature for one hour. Then, ice (300 g) was added. By filtering a precipitated white solid and then drying the white solid after washing with water, a target substance was obtained as a white solid (80% yield). 1H-NMR (400 MHZ, CDCl3, TMS) δ 8.12 (s, 1 H), 7.51 (s, 1 H)

Provenance & Evidence