反应详情

PBr3 (0.171 mL, 1.82 mmol, Aldrich) was added to a solution of 1-phenylpentan-1-ol (0.500 g, 3.04 mmol, Alfa Aesar) in Et2O (3.2 mL) at 0° C. The reaction was allowed to reach ambient temperature and then was quenched with ice water and diluted with hexanes. The layers were separated and the organic layer was washed with water and then with brine, dried over sodium sulfate, filtered and concentrated. Flash chromatography, eluting with hexanes afforded product (0.15 g, 22%).

1. customto reach ambient temperature
2. customwas quenched with ice water
3. additiondiluted with hexanes
4. customThe layers were separated
5. washthe organic layer was washed with water
6. dry with materialwith brine, dried over sodium sulfate
7. filtrationfiltered
8. concentrationconcentrated
9. washFlash chromatography, eluting with hexanes afforded product (0.15 g, 22%)