Azetidine → HCID 118159666, compound

HRID 628281Notes

Reaction equation

[CH3:1][C:2]1[N:6]2[C:7]3[CH:13]=[C:12]([CH3:14])[N:11]([CH2:15][C:16]4[CH:21]=[CH:20][C:19]([CH2:22]O)=[CH:18][CH:17]=4)[C:8]=3[CH:9]=[CH:10][C:5]2=[N:4][N:3]=1.[NH:24]1[CH2:27][CH2:26][CH2:25]1>>[N:24]1([CH2:22][C:19]2[CH:20]=[CH:21][C:16]([CH2:15][N:11]3[C:8]4[CH:9]=[CH:10][C:5]5[N:6]([C:2]([CH3:1])=[N:3][N:4]=5)[C:7]=4[CH:13]=[C:12]3[CH3:14])=[CH:17][CH:18]=2)[CH2:27][CH2:26][CH2:25]1

Participants

Reactant 2

HCID 10422Azetidine

HCID 118159705HCID 118159705, compound

Product 1

HCID 118159666HCID 118159666, compound

Procedure

The title compound was prepared according to the procedures of Example 45, using the alcohol of Example 49 as starting material and using azetidine (0.013 mL, 0.20 mmol, Aldrich) in the displacement, which was performed overnight (8.0 mg, 47%).

Sources & evidence

ORD record: ord-c6a8f5b97f914f39bb40b0d91f424e2f
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09309246B2

Reaction notes

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