反应详情

温度

110 °C

A mixture of 1-benzyl-2-bromo-5-chloro-1H-pyrrolo[3,2-b]pyridine (0.10 g, 0.31 mmol, from Example 62, Step 2) and 2-(tributylstannyl)pyridine (0.11 g, 0.31 mmol, Aldrich) in toluene (6.0 mL) was degassed by a stream of nitrogen through the solution for 10 minutes. Tetrakis(triphenylphosphine)palladium(0) (36 mg, 0.031 mmol) was added and the mixture was stirred at 110° C. for 6 hours. Solvent was removed in vacuo and the residue was dissolved in MeCN, filtered and concentrated. Flash chromatography, eluting with a gradient from 0-20% EtOAc in hexanes afforded desired product (40 mg, 40%).

1. customwas degassed by a stream of nitrogen through the solution for 10 minutes
2. customSolvent was removed in vacuo
3. dissolutionthe residue was dissolved in MeCN
4. filtrationfiltered
5. concentrationconcentrated
6. washFlash chromatography, eluting with a gradient from 0-20% EtOAc in hexanes