反应详情

温度

110 °C

A mixture of 1-benzyl-2-bromo-5-chloro-1H-pyrrolo[3,2-b]pyridine (0.10 g, 0.31 mmol, from Example 62, Step 2) and 1-methyl-4-(tributylstannyl)-1H-imidazole (0.12 g, 0.31 mmol, Aldrich) in toluene (6.0 mL) was degassed. Tetrakis(triphenylphosphine)palladium(0) (36 mg, 0.031 mmol) was added and the mixture was heated to 110° C. for 7 hours. Toluene was removed in vacuo and the mixture was dissolved in MeCN and filtered. Flash chromatography, eluting with a gradient from 0-70% EtOAc in hexanes afforded purified product (24 mg, 24%).

1. customwas degassed
2. customToluene was removed in vacuo
3. dissolutionthe mixture was dissolved in MeCN
4. filtrationfiltered
5. washFlash chromatography, eluting with a gradient from 0-70% EtOAc in hexanes
6. customafforded
7. custompurified product (24 mg, 24%)