反应详情

3,5-Difluoro-4-hydroxy-benzaldehyde obtained in Step A was dissolved in CH3CN (15 mL), and Cs2CO3(6.3 g, 19.23 mmol) was added to the solution. The mixture was cooled to 0˜5° C. Benzylbromide (1.1 mL, 9.23 mmol) was added slowly thereto, and the mixture was stirred at room temperature for 2 hours. After the termination of the reaction, the reactant was filtered and then concentrated under reduced pressure. The residue was purified by column chromatography (eluent, EtOAc/Hex=1/7) to obtain the title compound (1.76 g, 92%).

1. temperatureThe mixture was cooled to 0˜5° C
2. customAfter the termination of the reaction
3. filtrationthe reactant was filtered
4. concentrationconcentrated under reduced pressure
5. customThe residue was purified by column chromatography (eluent, EtOAc/Hex=1/7)