反应详情

To a solution of 2-(4-fluorophenyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole (44.5 g, 0.22 mol) in 600 mL chloroform is added at 0° C. N-bromosuccinimide (117 g, 0.66 mol). The mixture is stirred 17 h at RT. Thereafter, the mixture is diluted with water and extracted with dichloromethane. The combined organic phases are dried and evaporated. The obtained crude material is purified by column chromatography on silica (6 cm×40 cm, eluent dichloromethane). The obtained product is further purified by trituration with a MTBE-hexane mixture and 38.2 g (61%) of the product are obtained as solid.

1. extractionextracted with dichloromethane
2. customThe combined organic phases are dried
3. customevaporated
4. customThe obtained crude material
5. customis purified by column chromatography on silica (6 cm×40 cm, eluent dichloromethane)
6. customThe obtained product is further purified by trituration with a MTBE-hexane mixture and 38.2 g (61%) of the product
7. customare obtained as solid