Ammonia → HCID 118290392, compound

HRID 628485Notes

Reaction equation

HRID 628485 reaction equation
[CH:1]1([C:4]2[CH:28]=[CH:27][CH:26]=[C:25]([N:29]3[C:33](=[O:34])[N:32]([CH3:35])[N:31]=[N:30]3)[C:5]=2[CH2:6][O:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]3[C:15]([CH3:23])=[C:16]([C:20](Cl)=[O:21])[N:17]([CH3:19])[N:18]=3)=[CH:10][C:9]=2[CH3:24])[CH2:3][CH2:2]1.[NH3:36]>>[CH:1]1([C:4]2[C:5]([CH2:6][O:7][C:8]3[CH:13]=[CH:12][C:11]([C:14]4[C:15]([CH3:23])=[C:16]([C:20]([NH2:36])=[O:21])[N:17]([CH3:19])[N:18]=4)=[CH:10][C:9]=3[CH3:24])=[C:25]([N:29]3[C:33](=[O:34])[N:32]([CH3:35])[N:31]=[N:30]3)[CH:26]=[CH:27][CH:28]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 118290389HCID 118290389, compound

Product 1

HCID 118290392HCID 118290392, compound

Procedure

At room temperature, to 28%-Ammonia solution 50 ml was added 5-{4-[2-Cyclopropyl-6-(4-methyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-benzyloxy]-3-methyl-phenyl}-2,4-dimethyl-2H-pyrazole-3-carbonyl chloride (described in Reference Preparation example 117) 1.3 g. The mixture was stirred for twelve hours and concentrated under reduced pressure and added 10%-hydrochloric acid solution 10 ml. The precipitates were filtrated and were washed with water and were dried under reduced pressure to give 1-{3-cyclopropyl-2-[2-methyl-4-(5-aminocarbonyl-1,4-dimethyl-1H-pyrazol-3-yl)-phenoxymethyl]-phenyl}-4-methyl-1,4-dihydrotetrazole-5-one (hereinafter, referred to as “Present compound 49”) 0.8 g.

Workup

  1. concentrationconcentrated under reduced pressure
  2. additionadded 10%-hydrochloric acid solution 10 ml
  3. filtrationThe precipitates were filtrated
  4. washwere washed with water
  5. customwere dried under reduced pressure

Sources & evidence

ORD record
ord-8cc9059e53cd4ec4aaa8553072315f5e
Source dataset
uspto-grants-2016_04
Patent number
US09314023B2

Reaction notes

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