反应详情

(2-Butylsulfanyl-pyridin-3-yl)-methanol (0.85 g, 4.3 mmol) obtained in Step B was dissolved in CH3CN (20 mL). SOCl2(0.63 mL, 8.6 mmol) was added thereto, and the mixture was stirred at room temperature for 2 hours. After the termination of the reaction, the reactant was concentrated under reduced pressure to remove the solvent and then added with EtOAc. The organic layer was washed with water, dried with MgSO4, and concentrated under reduced pressure to obtain the title compound (0.77 g, 82%).

1. customAfter the termination of the reaction
2. concentrationthe reactant was concentrated under reduced pressure
3. customto remove the solvent
4. additionadded with EtOAc
5. washThe organic layer was washed with water
6. dry with materialdried with MgSO4
7. concentrationconcentrated under reduced pressure