(4-Methoxy-2,5-dimethylphenyl)boronic acid → 1-(2,5-dimethyl-4-methoxy-phenyl)-3-methyl-1H-pyrazole

HRID 628520Notes

Reaction equation

HRID 628520 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([CH3:10])=[CH:4][C:3]=1B(O)O.[CH3:14][C:15]1[CH:19]=[CH:18][NH:17][N:16]=1>>[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([CH3:10])=[CH:4][C:3]=1[N:17]1[CH:18]=[CH:19][C:15]([CH3:14])=[N:16]1

Participants

3

Reactant 2

HCID 5233015(4-Methoxy-2,5-dimethylphenyl)boronic acidHCID 178428694HCID 178428694, compound

Product 1

HCID 1182363091-(2,5-dimethyl-4-methoxy-phenyl)-3-methyl-1H-pyrazole

Procedure

A similar reaction to Reference Preparation example 33 using 2,5-dimethyl-4-methoxy-phenylboronic acid instead of 4-methoxy-3-methyl-phenylboronic acid, and using 3-methyl-1H-pyrazole instead of 3,4,5-trimethyl-1H-pyrazole gave 1-(2,5-dimethyl-4-methoxy-phenyl)-3-methyl-1H-pyrazole.

Workup

  1. customA similar reaction

Sources & evidence

ORD record
ord-ffd50c8f5d6b4c59841cd87e1aa05da9
Source dataset
uspto-grants-2016_04
Patent number
US09314023B2

Reaction notes

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