Isobutyl iodide → 2-Isobutylsulfanyl-nicotinic acid

HRID 62853Notes

Reaction equation

[SH:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH2:11](I)[CH:12]([CH3:14])[CH3:13]>>[CH2:11]([S:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5])[CH:12]([CH3:14])[CH3:13]

Participants

Reactant 2

HCID 10556Isobutyl iodide

HCID 178524460HCID 178524460, compound

Product 1

HCID 167867122-Isobutylsulfanyl-nicotinic acidYield 92%

Procedure

2-Mercapto-nicotinic acid (2 g, 12.8 mmol) and isobutyliodide were reacted in the same manner as in Step A of Preparation Example 10 to obtain the title compound (2.175 g, 92%).

Sources & evidence

ORD record: ord-32170a2f8df84962a9cc09c372d8ff78
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09447044B2

Reaction notes

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